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Lisa Marie Simpson is a fictional main character in the animated television series The Simpsons. She is the middle child of the Simpson family. Voiced by Yeardley Smith, Lisa first appeared on television in The Tracey Ullman Show short "Good Night" on April 19, 1987. Cartoonist Matt Groening created and designed her while waiting to meet James L. Brooks.

Groening had been invited to pitch a series of shorts based on his comic Life in Hell, but instead decided to create a new set of characters. He named the elder Simpson daughter after his younger sister Lisa Groening. After appearing on The Tracey Ullman Show for three years, the Simpson family were moved to their own series on Fox, which debuted on December 17, 1989.

At eight years old, Lisa is the second child of Homer and Marge, younger sister of Bart and older sister of Maggie. She is highly intelligent and plays the baritone saxophone. She has been a vegetarian since season 7, converted to Buddhism in season 13 and advocates for a variety of political causes, including the Tibetan independence movement. She has appeared in other media relating to The Simpsons – including video games, The Simpsons Movie, The Simpsons Ride, commercials and comic books – and inspired a line of merchandise.

Yeardley Smith originally tried out for the role of Bart, while Nancy Cartwright (who was later cast as the voice for Bart) tried out for Lisa.

Producers considered Smith's voice too high for a boy, so she was given the role of Lisa. In the Tracey Ullman Show shorts, Lisa was something of a "female Bart" who mirrored her brother's mischief, but as the series progressed she became a more sophisticated and intellectual character. Because of her unusual pointed hair style, many animators consider Lisa the most difficult Simpsons character to draw.

Lisa is one of the most enduring characters on the series. TV Guide ranked her eleventh (tied with Bart) on their list of the "Top 50 Greatest Cartoon Characters of All Time". Her environmentalism has been especially well received; several episodes featuring her have won Genesis and Environmental Media Awards, including a special "Board of Directors Ongoing Commitment Award" in 2001. People for the Ethical Treatment of Animals included Lisa on their list of the "Most Animal-Friendly TV Characters of All Time".

Yeardley Smith won a Primetime Emmy Award for Outstanding Voice-Over Performance in 1992, and in 2000 Lisa and her family were awarded a star on the Hollywood Walk of Fame.

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