Ergo Proxy (Erugo Purakushi) is a science fiction suspense anime television series, produced by Manglobe, which premiered across Japan on 25 February 2006 on the WOWOW satellite network.  It is directed by Shuko Murase, with screenplay by Dai Sato et al..  Ergo Proxy has been described as dark science fiction mystery with philosophical underpinnings.  It features a combination of 2D digital cel animation, 3D computer modeling, and digital special effects.

The story begins in a futuristic domed city called Romdeau, built to protect its citizens after a global ecological disaster thousands of years ago.  In this utopia, humans and AutoReivs (androids) coexist peacefully under a total management system.  A series of murders committed by robots and AutoReivs infected with the Cogito virus (which causes them to become self-aware) begins to threaten the delicate balance of Romdeau's social order.  Behind the scenes, the government has been conducting secret experiments on a mysterious humanoid life form called a "Proxy".  The Proxy beings (described as God-like and Immortal) are believed to hold the key to the survival of mankind.

Re-l (pronounced "Rielle", also represented by the spelling "REAL" in the Romdeau citizen database) Mayer is assigned to investigate some of the murders with her AutoReiv partner, Iggy.  She encounters a Cogito virus-infected AutoReiv and a fast and flexible monster.  She later learns that the monster was a Proxy.  The other central character, an immigrant named Vincent Law, is revealed to be connected in some ways with this Proxy.  After being hunted down, Vincent lives for a while on the outside of the dome.  He later leaves for Mosk, his birthplace, in an attempt to recover his memories.  Re-l rejoins him to try to discover the truth behind the Proxies and the domes.  It is revealed among other things that domes are all created by Proxies as well as the people inhabiting them who are created in special incubators.

In the Romdeau arcology, the government is divided between several entities: the Intelligence Bureau, the Health & Welfare Bureau, and the Security Bureau, are named in the series, all under the control of an Administrator who is referred to as the grandfather of "REAL".

The primary AutoReiv types are referred to as either 'Companion' or 'Entourage', depending on their role.  There are others designed for leisure or combat functions; AutoReivs seem to be constructed of varying degrees of cybernetic complexity, as witnessed by AutoReivs on occasion producing blood splatter when shot and killed.
The humans in the city are grown in artificial wombs.  Numerous times throughout the series it is stated that the humans living in the domes have no capacity to reproduce naturally.  Likewise, when a new person is grown, they are done so to fulfill a specific purpose, thus ensuring that person's future place in society through a "raison d'être" (i.e., a "reason for being").

A number of characters in the supporting cast are named after various figures taken from both history as well as mythology.  Most notably, names of significant profiles in philosophical and psychological sciences appear throughout the series.  The Proxies could almost be supporting characters, since they play such a vital role in the series.  Though it is stated that there are many Proxies, only a few have been named: Monad, Senex, Kazkis and Ergo Proxies, as well as Proxy One, MCQ and Will B.  Good.  A sixth which Re-l sends back to Romdo with Iggy, is never named.

Re-l Mayer
Voiced by: Rie Saito (Japanese), Megan Hollingshead (English)(credited as Karen Thompson)
Inspector Re-l Mayer of the Citizen Intelligence Bureau (Shimin Johokyoku?) is in charge of investigating a series of brutal murders apparently committed by AutoReivs infected with the Cogito virus.  She is also the granddaughter of Donov Mayer, the Regent of Romdo.  Given her privileged status, she expects respect from people around her, and speaks as such (she addresses Vincent as "o-mae").  Re-l accompanies Vincent on his journey in order to learn more about the mysterious Proxies.

Vincent Law
Voiced by: Koji Yusa (Japanese), Liam O'Brien (English)
An immigrant from Mosk working for Romdo's AutoReiv Control Division within the Temporary Immigrant Sector FG, set up to hunt and dispose infected AutoReivs.  Vincent appears driven to become a Model Citizen, but ultimately fails to suppress the burden of his traumatic past and flees from Romdo.  He seems to have a deep connection to the second Proxy, having left his necklace at the scene of the first Proxy site.

Pino
Voiced by: Akiko Yajima (Japanese), Rachel Hirschfeld (English)
An infected Companion type AutoReiv owned by Raul Creed and Samantha Ross, Pino served as a surrogate child to the couple.  She was scheduled for decommissioning after the Creeds were granted a real baby son by the government, but the untimely deaths of Samantha and her new son prompted Pino to flee Romdo.  She accompanies Vincent on his journey.  The character of Pino was given this name as a reference to Pinocchio, and Pinoko from Osamu Tezuka's Black Jack.  and also to the painter Pino Daeni.

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